Ghrelin is a hormone is made in the stomach. When Ghrelin
is manufactory in our stomach and pump out into our system, we get hungry. It
is one of the factors in our body to tell us we are hungry.
Receptors for ghrelin are expressed by neurons in the arcuate
nucleus and the lateral hypothalamus. The ghrelin receptor is a
G protein-coupled receptor, formerly known as the GHS receptor (growth hormone
secretagogue receptor).
Ghrelin plays a significant role in neurotrophy,
particularly in the hippocampus, and is essential for
cognitive adaptation to changing environments and the process of learning.
Recently, ghrelin has been shown to activate the endothelial isoform of nitric
oxide synthase in a pathway that depends on various kinases including Akt.
Ghrelin exists in an endocrinological
inactive (pure peptide) and an active (octanoylated) form (Hexatropin)
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